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KMID : 1123920050190030716
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Korean Journal of Oriental Physiology and Pathology
2005 Volume.19 No. 3 p.716 ~ p.721
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Effect of Farfarae Flos Extract Drug on Immune Cells and Cytokines in BALF of OVA-induced Asthmatic Mice
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Kwak Sang-Kyo
Choi Sun-Mi
Park Yang-Chun
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Abstract
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This experiment was designed to investigate the effect of Farfarae Flos(FF) on immune cells and cytokines in murine asthma model. C57BL/6 mice were sensitized and challenged with OVA(ovalbumin) for 9 weeks(3 times a week). The experimental group was treated with Farfarae Flos extract(FF) for the later 6 weeks(5 times a week). We measured IL-4, 1L-5, 1L-13, IgE, IFN- in bronchoalveolar lavage fluid of ovalbumin induced asthmatic mouse and observed murine lung tissue. The results were obtained as follows: Total leukocytes and eosinophils in BALF of the mice group treated with FF decreased significantly compared with those of control group. The concentration of IL-4, IL-5, IL-13, IgE in BALF of the mice group treated with FF decreased significantly compared with those of control group. The concentration of IFN- in BALF of the mice group treated with FF increased significantly compared with that of control group. According to the above results, it is suggested that FF extract might be useful applied for prevention and treatment of allergic asthma.
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KEYWORD
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Farfarae Flos(FF), IL-4, 1L-5, 1L-13, IgE, asthmatic mouse
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